The 1002 Yeast Genomes project first began as the ambitious next step to understanding this important model species. The project represents the efforts of a collaboration between Joseph Schacherer’s laboratory at the Université de Strasbourg, Gianni Liti’s laboratory at the Institute for Research on Cancer and Aging (IRCAN) in Nice, the Genoscope and has been funded in a large part by France Génomique. The primary goal of this project was to obtain the most comprehensive genomic data set to date, on a single species of yeast (S. cerevisiae), and ultimately provide the most extensive view of the genetic and phenotypic diversity within this model species to date. In total the project was originally slated to include 1002 strains from diverse global locations (including Australia, Europe, Russia, Vietnam and South Africa), as well as a variety of ecological sources, such as dairy products, trees, insects, flowers, fruit and wine. At this point, we have obtained a total of 1026 whole genome sequences soon to be available.
Publications :
- Matteo De Chiara et al. Discordant evolution of mitochondrial and nuclear yeast genomes at population level BMC Biology 2020, vol. 18, issue 1
- Melania D’Angiolo et al. A yeast living ancestor reveals the origin of genomic introgressions Nature 2020, vol. 587, issue 7834
- Hayley R Stoneman et al. CRISpy-Pop: A Web Tool for Designing CRISPR/Cas9-Driven Genetic Modifications in Diverse Populations G3 Genes|Genomes|Genetics 2020, vol. 10, issue 11
- Peter J et al. Genome evolution across 1,011 Saccharomyces cerevisiae isolates Nature 2018 556(7701)
- Duyen T Bui et al. Mismatch Repair Incompatibilities in Diverse Yeast Populations Genetics 2017, vol. 205, issue 4
- Benjamin Istace et al. de novo assembly and population genomic survey of natural yeast isolates with the Oxford Nanopore MinION sequencer GigaScience 2017, vol. 6, issue 2